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                                                   C   1               	      0                       	                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            	                                                                                              	              
                  	 	           
                 C 1     	  0   PÔ  Qj  Qz  Qš  S¾  Vp  Y²Z mP. °%®Lú²É	b˜…	º‡k!÷<ô ÙùÚBBPW² ² ä ë ô ‹›tyŒÜßâ(êó7<¾äd§U
Ù8³b¬Q³b³b³³˜_þe�
èß>r
ß™á7áoºfž¡Ôt
Í
~- ºý ÿ ÁCœ{Eê .{ê3´¥®H½ƒ6�Ië%‡hù	ê ýê° �$	­° $	šà?ê° Õ‚$	6¬ �Ê—ÿê j”»²µk”šoó²	Xê lÞê ¬äº.z{ê/3‘º�Û¼Z	,To
ÓÖªaK~åŠC¯¸K	Š�SU·�ÒE	Ô�ÄW“;	Ök2 ° Õ ‚�$	­º
ªê!p|‡ /3�”˜yëæó<Çæê6£ùN
Õ$ ”ê¬k
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àâAàš1é8 ,àTZ	o
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š»Sgz‘àñÏ. Q e	|  žA2Ò
µ#»zñÏ( èÿ�	„	R
ý FÜßâŒ:‹�@	šb‹&i‚ÎL�uÐ	( • ý F’ÜßâåèŒ¾ÿ:‹� ±@	�	„	R
šígL. Q aKå~‹e	|˜ ä \•GB^M Ï ¿0�µ}	Š	>l†"ÿ	•6íL @]HS'âý–
<ª Xº{ 5 ,d#0Äá	ª â8ý–
<X‡e]˜
-–ñœØ?‚|	‰	P’
k t€­q { MS£4€aE†Ñ]	bs€u�ÿsOip › g£Z¨	
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ÔßWnvjÐ
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"˜;qÏ
Â}]	£†b8 oh;4€aEÑ• ’å¾ ±ígL‡œØe]?‚|	‰	˜
-–ñ1Cë
¿Q€f)  j ðòLPR]
§”àÈ â “®¿´u3²Å>	3
¦î“àMßJ q { • » å(MS] §¼¬	<
Àg°§ }|F* = 2��êÐ;éí‚šù9¯‘	
#‡Æ i ë  }ÂñQmŽœßC	ñ	^
çD•á§‰ùëHÙ	Ö
%­BP¡ªºÙv!
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¸Ú‹}% •ÁŽn’ë»
¦°þ"«* = ^ † Š ü 2„�7#N�‘ê!Vp¥Ðåö;DTgÝåéí‚šÎãù9Jœ¯ø/‘		7	†	Ç	Ò	ý	
…‘ºÔØá#}‡Æì% ’ ¶ ¸ •Áü'0CHO¸¿ÌóªY™¯Žn’—È×ë+t¥	»
Wz¦°þ"d›x«·u©
I¾þ' ± H“›£FÕþB<%	M
œö·÷þˆ&ˆ«¼ã
  ê<‘áß{–Òª¢QãZ]¡	1‚� R²æ@¬
à
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(:§ * = 2u�ž=‘�½êò7Ð;éí‚šù-9¯^‘¿÷
		¢	

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6#I‡Æ¾ùþ¡@Øá…Nò   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  <?xml version="1.0"?><Features nextValidID="11"><Feature recentID="0" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1710-1726" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1686-1702" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="M13 fwd" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="379-395" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1779-1800" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment name="-10" range="1734-1740" color="#ffffff" type="standard"/><Segment range="1741-1758" color="#ffffff" type="standard"/><Segment name="-35" range="1759-1764" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3708-3812" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1524-1658" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="copia promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="501-780" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;strong promoter from the &lt;i&gt;Drosophila&lt;/i&gt; transposable element &lt;i&gt;copia&amp;nbsp;&lt;/i&gt;&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/16453706&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/16453706&quot;&gt;(Sinclair et al., 1986)&lt;/a&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="BSD" directionality="1" translationMW="13668.05" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="797-1195" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;Aspergillus terreus BSD&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to blasticidin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;blasticidin S deaminase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MAKPLSQEESTLIERATATINSIPISEDYSVASAALSSDGRIFTGVNVYHFTGGPCAELVVLGTAAAAAAGNLTCIVAIGNENRGILSPCGRCRQVLLDLHPGIKAIVKDSDGQPTAVGIRELLPSGYVWEG*"/></Q></Feature><Feature recentID="9" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2088-2676" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="3638" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="2847-3638" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="3639-3707" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSIQHFRVALIPFFAAFCLPVFA,HPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW*"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ”<Notes>
<UUID>2401a317-0c44-4bb3-9666-765a275217be</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pCoBlast</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Created UTC="6:18:13">2018.1.23</Created>
<LastModified UTC="4:43:33">2025.8.26</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Y     K         
?????                                                                                                       ÿ d      DO  d              E              ÿÿÿÿYô? P                                                                                                                                                             <StrandColors><TopStrand><ColorRange range="796..1194" colors="light blue"/><ColorRange range="2751..3723" colors="purple"/></TopStrand><BottomStrand><ColorRange range="796..1194" colors="light blue"/><ColorRange range="2751..3723" colors="purple"/></BottomStrand></StrandColors>   3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
